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Is The Psa Test Recommended For Prostate Cancer Screening

Routine Bloodwork Leads to Prostate Cancer Diagnosis | Kaiser Permanente

Beginning around 2008, as more was learned about both the benefits and harms of prostate cancer screening, a number of professional medical organizations began to caution against routine population screening with the PSA test. Most organizations recommend that individuals who are considering PSA screening first discuss the risks and benefits with their doctors.

Some organizations do recommend that men who are at higher risk of prostate cancer begin PSA screening at age 40 or 45. These include Black men, men with germline variants in BRCA2 , and men whose father or brother had prostate cancer.

In 2018, the United States Preventive Serves Task Force updated its recommendation statement for prostate cancer screening from a D to a C in men ages 55 to 69. The updated recommendation, which applies to the general population as well as those at increased risk due to race/ethnicity or family history, is as follows:

  • For individuals ages 55 to 69 years, the decision to undergo periodic PSA-based screening for prostate cancer should be an individual one. Before making the decision, a person should discuss the potential benefits and harms of screening with their clinician and consider these in the context of their own values and preferences.
  • PSA-based screening for prostate cancer is not recommended for individuals 70 years and older.

What Is The Controversy Surrounding Psa Screening

In recent years, there has been some controversy surrounding the PSA test. In 2012, the U.S. Preventive Services Task Force assigned the PSA test a D rating. This meant that the USPSTF concluded the harms that resulted from PSA testing, such as unnecessary biopsies and negative treatment side effects, outweighed the benefits of finding and managing the disease early. This recommendation did not include exceptions for men at increased risk of developing the disease, such as African American men, those with a family history of the disease, and those with BRCA gene mutations. The USPSTF recommendation is important as it guides primary care physicians in preventive care and can impact insurance coverage and reimbursement for screening. Prior to its D rating, the PSA test had an I rating, meaning the USPSTF concluded there was insufficient evidence to assess the pros and cons of testing.

In May 2018, the USPSTF updated their recommendation on PSA screening. In response to new research demonstrating the benefits of PSA screening , an increase in the number of men choosing active surveillance, and advocacy efforts, the USPSTF released a draft recommendation in April 2017 that assigns the PSA test a C rating for men ages 55 to 69 . This rating has now been certified official by the task force.

Advanced Genomic Testing For Prostate Cancer

The most common lab test for prostate cancer is advanced genomic testing, which examines a tumor to look for DNA alterations that may be driving the growth of the cancer. By identifying the mutations that occur in a cancer cells genome, doctors may get a clearer picture of the tumors behavior and be able to tailor a patients treatment based on the findings.

Expert cancer care

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What Is Prostate Cancer

This diagram shows the location of the prostate, in front of the rectum and just below the bladder.

Cancer is a disease in which cells in the body grow out of control. When cancer starts in the prostate, it is called prostate cancer. Not including skin cancer, prostate cancer is the most common cancer in American men.

How Soon Will Prostate Test Results Be Available

Prostate cancer diagnostics test

Results for simple medical tests such as some urodynamic tests, cystoscopy, and abdominal ultrasound are often available soon after the test. The results of other medical tests such as PSA blood test and prostate tissue biopsy may take several days to come back. A health care provider will talk with the patient about the results and possible treatments for the problem.

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Biopsy During Surgery To Treat Prostate Cancer

If there is more than a very small chance that the cancer might have spread , the surgeon may remove lymph nodes in the pelvis during the same operation as the removal of the prostate, which is known as a radical prostatectomy .

The lymph nodes and the prostate are then sent to the lab to be looked at. The lab results are usually available several days after surgery.

What Are Normal Psa Levels

Thereâs no such thing as a normal PSA for any man at any given age, but most men with prostate cancer have a higher than normal level. In general:

If your PSA results are in the borderline range , the % free PSA can be useful in helping distinguish between prostate cancer or benign prostatic hyperplasia . The pattern is the opposite of that seen with PSA in that a high % free PSAâabove 20%âpoints to BPH, while a %- free PSA less than 10% indicates a greater likelihood of cancer.

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What Does A High Psa Level Mean

High PSA levels could be a sign of prostate cancer or a different condition like prostatitis or an enlarged prostate.

Other things can affect your PSA level:

  • Age. Your PSA will normally go up slowly as you get older, even if you have no prostate problems.
  • Medications. Some drugs may affect blood PSA levels. Tell your doctor if youâre taking dutasteride or finasteride . These drugs may falsely lower PSA levels by half of what they should be.

If your PSA level is high, your doctor may suggest that you get a prostate biopsy to test for cancer.

Getting A Prostate Biopsy

Avoid prostate biopsies with new cancer screening

For some men, getting a prostate biopsy might be the best option, especially if the initial PSA level is high. A biopsy is a procedure in which small samples of the prostate are removed and then looked at under a microscope. This test is the only way to know for sure if a man has prostate cancer. If prostate cancer is found on a biopsy, this test can also help tell how likely it is that the cancer will grow and spread quickly.

For more details on the prostate biopsy and how it is done, see Tests to Diagnose and Stage Prostate Cancer.

For more information about the possible results of a prostate biopsy, see the Prostate Pathology section of our website.

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What’s A Raised Psa Level

The amount of PSA in your blood is measured in nanograms of PSA per millilitre of blood .

If you’re aged 50 to 69, raised PSA is 3ng/ml or higher.

A raised PSA level in your blood may be a sign of prostate cancer, but it can also be a sign of another condition that’s not cancer, such as:

What Are Additional Tests For Detecting Prostate Problems

If the DRE or the PSA blood test indicates a problem may exist, the health care provider may order additional tests, including urinalysis, urodynamic tests, cystoscopy, abdominal ultrasound, transrectal ultrasound with prostate biopsy, and imaging studies such as magnetic resonance imaging or computerized tomography scan.

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What Is Screening For Prostate Cancer

Some men get a PSA test to screen for prostate cancer. Talk to your doctor, learn what is involved, and decide if a PSA test is right for you.

Cancer screening means looking for cancer before it causes symptoms. The goal of screening for prostate cancer is to find cancers that may be at high risk for spreading if not treated, and to find them early before they spread.

If you are thinking about being screened, learn about the possible benefits and harms of screening, diagnosis, and treatment, and talk to your doctor about your personal risk factors.

There is no standard test to screen for prostate cancer. Two tests that are commonly used to screen for prostate cancer are described below.

Research Into Prostate Cancer Screening

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Research is ongoing to find other prostate cancer screening tests and ways to improve the current test. This includes:

  • new blood and urine tests
  • a combination of a blood test and other information such as age and family history
  • MRI and other types of scans

More research is needed to find out whether these tests are reliable enough to detect prostate cancer.

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Using The Psa Blood Test After Prostate Cancer Diagnosis

Although the PSA test is used mainly to check for prostate cancer, it can also help your doctor:

  • Choose a treatment. Along with an exam and tumor stage, the PSA test can help determine how advanced a prostate cancer is. This may affect treatment options.
  • Check treatment success. After surgery or radiation, the doctor can watch your PSA level to see if the treatment worked. PSA levels normally fall if all of the cancer cells were removed or destroyed. A rising PSA level can mean that prostate cancer cells are present and your cancer has returned.

If you choose a watchful waiting approach to treatment, your PSA level can tell your doctor if the disease is progressing. If so, youâll need to think about active treatment.

During hormone therapy, the PSA level can show how well the treatment is working and when itâs time to try another treatment.

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Why The Test Is Performed

Reasons for a PSA test:

  • This test may be done to screen for prostate cancer.
  • It is also used to follow people after prostate cancer treatment to see if the cancer has come back.
  • If a provider feels the prostate gland is not normal during physical exam.

MORE ABOUT SCREENING FOR PROSTATE CANCER

Measuring the PSA level can increase the chance of finding prostate cancer when it is very early. But there is debate over the value of the PSA test for detecting prostate cancer. No single answer fits all men.

For some men 55 through 69 years old, screening may help reduce the chance of death from prostate cancer. However, for many men, screening and treatment could potentially be harmful instead of beneficial.

Before having the test, talk to your provider about the pros and cons of having a PSA test. Ask about:

  • Whether screening decreases your chance of dying from prostate cancer
  • Whether there is any harm from prostate cancer screening, such as side-effects from testing or overtreatment of cancer when discovered

Men younger than age 55 have a higher chance of developing prostate cancer and should talk with their provider about PSA screening if they:

  • Have a family history of prostate cancer
  • Are African American

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New Prostate Cancer Blood Test

If you have an abnormal PSA score, your doctor may recommend another newertest that gives a better sense of yourprostate cancer risk. The prostate health index is one such test that is a more accurateblood test and measures your risk for having prostate cancer. Its approvedby the FDA for men who have PSA scores between 4 and 10.

What are the benefits of the PHI test?

  • Fewer unnecessary biopsies: Some men who have elevated PSA scores are unsure about getting an invasive biopsy. This tool can be used to better determine whether your risk is high enough to warrant a biopsy.
  • More accurate: This test is better at detecting prostate cancer. It can also detect whether you have a more aggressive type of cancer. This information can guide doctors to a more targeted treatment plan for you.

If you score low on the PHI test, your doctor may recommend monitoring youover time to see if your levels rise enough to cause concern.

How Do I Interpret My Test Results

Explained: PSA testing for prostate cancer – Online interview

With some laboratory tests, the results obtained for healthy people can vary somewhat from person to person. Factors that can cause person-to-person variation in laboratory test results include a person’s age, sex, race, medical history, and general health. In fact, the results obtained from a single person given the same test on different days can also vary. For these tests, therefore, the results are considered normal if they fall between certain lower and upper limits or values. This range of normal values is known as the “normal range,” the “reference range,” and the “reference interval.” When healthy people take such tests, it is expected that their results will fall within the normal range 95 percent of the time. Reference ranges are based on test results from large numbers of people who have been tested in the past.

Some test results can be affected by certain foods and medications. For this reason, people may be asked to not eat or drink for several hours before a laboratory test or to delay taking medications until after the test.

For many tests, it is possible for someone with cancer to have results that fall within the normal range. Likewise, it is possible for someone who doesn’t have cancer to have test results that fall outside the normal range. This is one reason that many laboratory tests alone cannot provide a definitive diagnosis of cancer or other diseases.

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Pros And Cons Of The Psa Test

Pros:

  • it may reassure you if the test result is normal
  • it can find early signs of cancer, meaning you can get treated early
  • PSA testing may reduce your risk of dying if you do have cancer

Cons:

  • it can miss cancer and provide false reassurance
  • it may lead to unnecessary worry and medical tests when there’s no cancer
  • it cannot tell the difference between slow-growing and fast-growing cancers
  • it may make you worry by finding a slow-growing cancer that may never cause any problems

What Is The First Test For Detecting Prostate Problems

The first test for detecting prostate problems is a blood test to measure prostate-specific antigen , a protein made only by the prostate gland. This test is often included in routine physical exams for men older than age 50. Because African American men have higher rates of getting, and dying from, prostate cancer than men of other racial or ethnic groups in the United States, medical organizations recommend a PSA blood test be given starting at age 40 for African American men. Medical organizations also recommend a PSA blood test be given starting at age 40 for men with a family history of prostate cancer. Some medical organizations even recommend a PSA blood test be given to all men starting at age 40.

If urination problems are present or if a PSA blood test indicates a problem, additional tests may be ordered. These tests may require a patient to change his diet or fluid intake or to stop taking medications. If the tests involve inserting instruments into the urethra or rectum, antibiotics may be given before and after the test to prevent infection.

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Use In Men Already Diagnosed With Prostate Cancer

The PSA test can also be useful if you have already been diagnosed with prostate cancer.

  • In men just diagnosed with prostate cancer, the PSA level can be used together with physical exam results and tumor grade to help decide if other tests are needed.
  • The PSA level is used to help determine the stage of your cancer. This can affect your treatment options, since some treatments are not likely to be helpful if the cancer has spread to other parts of the body.
  • PSA tests are often an important part of determining how well treatment is working, as well as in watching for a possible recurrence of the cancer after treatment .

Medical History And Physical Exam

Prostate Cancer Diagnosis: The Prostate Biopsy

If your doctor suspects you might have prostate cancer, you will be asked about symptoms you are having, such as any urinary or sexual problems, and how long you have had them. You might also be asked about possible risk factors, including your family history.

Your doctor will also examine you. This might include a digital rectal exam , during which the doctor inserts a gloved, lubricated finger into your rectum to feel for any bumps or hard areas on the prostate that might be cancer. If you do have cancer, the DRE can sometimes help tell if its only on one side of the prostate, if its on both sides, or if its likely to have spread beyond the prostate to nearby tissues. Your doctor may also examine other areas of your body.

After the exam, your doctor might then order some tests.

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Problems With The Psa Test

There are reasons doctors donât agree on whether you need this test:

  • Finding prostate cancer early doesnât always protect you. The PSA test often finds small, slow-growing tumors that arenât life-threatening. Treating them anyway, whether itâs with surgery or radiation, can expose you to harmful side effects and complications. Also, finding cancer early may not help if you have an aggressive tumor or if it spread to distant body parts before you found it.
  • The results arenât always accurate. If you have a high level but you donât have cancer, the test results can create a lot of worry and lead to medical procedures you donât need. A negative result if you really do have cancer can prevent you from getting treatment you do need.

Other Factors That Influence Psa Levels

The PSA blood test alone cannot diagnose prostate cancer. It is possible, although rare, to have prostate cancer without raised PSA levels in the blood. A higher-than-normal PSA level doesnt automatically indicate prostate cancer either. A high PSA level is due to cancer in around one in three cases.

PSA levels can be raised by other factors, including:

  • , also known as benign prostatic enlargement .

For this reason, the PSA blood test isnt used in isolation when checking for prostate cancer.

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