White Button Mushrooms May Help In Early Stages Of Prostate Cancera Less Toxic Approach
This NCI-sponsored clinical trial is an example of rigorous, scientific research aimed to assess the potential role of mushroom-derived supplements in prostate cancer therapy.1
Dr. Przemyslaw Twardowski, Professor of Medical Oncology and Urologic Oncology at Saint Johns Cancer Institute, is a principal investigator for this groundbreaking clinical trial, which assesses the benefits of nutritional supplements in patients with early stages of prostate cancer.
Benefits Of Turkey Tail Mushrooms
In addition to helping your immune system and warding off malignant cells, turkey tail mushrooms provide the following health benefits.
- Influence on the immune system
Polysaccharides, a kind of carbohydrate abundant in these mushrooms, have been shown to promote the health of immune cells. Polysaccharide Peptides and Krestin may be found in turkey tails in abundance . These may help your immune system by increasing your immunological response and lowering inflammation at the same time. White blood cell counts are increased by PSP, while macrophages, a kind of white blood cell that may fight off dangerous pathogens, are activated by PSK.
- Antioxidants in abundance
Chronic inflammation and cellular damage are both possible outcomes of oxidative stress. The use of antioxidants may mitigate oxidative stress. Flavonoids and phenols in turkey tail mushrooms have been demonstrated to lower inflammation and trigger the production of critical protective substances that may improve your immune system. Turkey tail mushrooms include these antioxidants.
- This substance might inhibit cancer cell proliferation.
Studies have shown that turkey tail mushrooms may be able to halt the growth of cancerous cells and that it aids in treating cancer alternatively. Research has focused on the following areas:
- Cancer of the breast
- Cancer of the colon
- Cancer of the lungs
- Increased resistance and immunity
- Digestive health is improved.
Cbd And Mitochondria Function With Cancer
The little power plants of our cells are key players in this whole process.
After all, cancer cells have an unending supply of energy to grow and multiply which is part of the process.
Mitochondria not only may be suspect in the origins of cancer but also in its progression.
Just one more pathway with CBD:
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Turkey Tail Mushrooms Benefits
Here are some ways turkey tail mushrooms can help you stay healthy by boosting your immune system and fighting off cancerous cells.
These mushrooms have a high volume of polysaccharides, a type of carbohydrate that can improve the health of immune cells. In particular, turkey tails are full of Krestin and Polysaccharide Peptides . These can support your immune system by boosting your immune response while reducing inflammation.
PSP has been shown to increase white blood cell levels, while PSK activates macrophages, which are a specific type of white blood cell that can protect your body from harmful bacteria.
Oxidative stress can lead to chronic inflammation and cellular damage. Antioxidants can reduce the damage caused by oxidative stress.
There are several antioxidants in turkey tail mushrooms, including flavonoids and phenols, which have been shown to reduce inflammation and stimulate the release of essential protective compounds that can boost your immune function.
Some studies have found evidence that turkey tail mushrooms can actually stop cancer cells from growing. In particular, there have been studies related to :
How Do I Take Turkey Tail Mushroom
In traditional Asian medicine, turkey tail mushrooms have often been brewed as a tea. Many people still prefer this option.
It can also be consumed in powder form or even made into capsules. You can add a little turkey tail mushroom powder to a smoothie or make a broth with it. Just be sure to carefully follow the instructions on the package.
Depending on the outcomes of ongoing research, there may be even more options in the future if your doctor thinks it might help you recover from cancer.
Recently, researchers have found that different parts of the mushroom may provide different benefits.
In fact, a 2019 study found that a fermented substrate of the turkey tail mushroom seemed to have unique beneficial components compared with other parts of the mushroom.
Although these results are promising, people with cancer shouldnt try turkey tail before consulting with their oncologist. Its important to discuss your interest in any alternative treatment for cancer with your doctor to make sure its a safe and appropriate choice for your health.
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Research Into Mushrooms As A Cancer Treatment
Research has looked at some particular mushrooms and their extracts. This includes:
Used for centuries in Eastern Ancient medicine, this extract is believed to refresh bodies and extend life.
Phellinus linteus is known as song gen in Chinese medicine, sang-hwang in Korean and meshimakobu in Japanese.
Studies have shown that this type of mushroom extract slows the growth of breast cancer cells in the laboratory. It has also been shown to have anti cancer effects on skin, lung and prostate cancer cells.
We have to be cautious about such early research. Substances that can kill cells in laboratory conditions don’t necessarily turn out to be useful treatments in people.
Why People With Cancer Use It
Mushrooms are used in Japan and China to treat lung diseases and are sometimes given alongside cancer treatment. Research is looking at whether mushrooms can help the immune system.
It is thought that some of the chemical compounds in mushrooms might strengthen the immune system. If they do, researchers wonder if this could help fight cancer cells.
Button mushrooms and flat mushrooms are commonly eaten in the UK. They contain all the essential amino acids and are a good source of vitamins. So they can be used as part of a healthy diet. But there is no evidence that they can treat cancer.
In the UK, powdered shiitake, maitaki and reishi mushrooms are available. You can also sometimes get preparations of their juices. These are sold in health food shops.
As far as we know, there is nothing in the mushrooms or compounds that would be harmful but we don’t currently know how helpful they are in cancer care.
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Orthotopic Implantation Of Pc
The orthotopic model was established with procedures described previously . Briefly, eight-week-old CB-17 SCID mice were anesthetized and placed under a dissecting microscope. An incision at the midline of the abdomen was made, exposing the dorsal prostate at the base of the bladder. Equal amounts of viable PC3-luc cells with or without prior PSP treatment were injected into the dorsal prostates of the mice. The organs were replaced, and the abdomen was closed. Tumor development was monitored by measuring the bioluminescent signal every two weeks for six weeks after tumor implantation. Mice were sacrificed at the end of the experiment and prostate tissues were collected for physical examination. Statistical difference was determined by a two-tailed t-test and was considered significant if p< 0.05. All surgical and animal handling procedures were carried out according to the guidelines of the Committee on the Use of Live Animals in Teaching and Research , The University of Hong Kong.
Why White Button Mushrooms
Dr. Twardowski and his collaborators previously evaluated tablets derived from white button mushroom in patients who had evidence of relapse of prostate cancer after prior therapy with surgery, with and without radiation. Treatment with white button mushrooms has indicated a decrease in Prostate-specific Antigen in about 1/3 of patients while some of them experienced durable remissions. High PSA levels often point to the presence of prostate cancer or developing cancer. Targeting people who already have cancer makes it easier to identify the benefit of white button mushrooms.
Even though the exact biological effects of white button mushrooms are not fully known, analysis of blood samples of patients who responded to white button mushroom therapy suggested that anti-cancer activity might have been mediated by a favorable impact on the immune function. More so, various natural products have been linked to possible anti-cancerous effects, however, there is still no scientific evidence to purport those claims.
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Prolonging Psp Consumption Inhibits Prostate Cancer Development In Tgmap Mice
The failure to inhibit PIN formation by PSP treatment may due to insufficient dose or treatment length. We therefore tested if a higher dose and longer period of PSP consumption may affect prostate tumor formation using the same model. Five TgMAP mice were fed with 300 mg/kg of PSP for a total of 20 weeks . Four mice at the same age were again fed with water only for the same period of time. All mice were sacrificed at 28 weeks old when prostate tumors were formed, with prostatic tissues collected and sectioned for histology. As shown in Figure 5B, tumors were found in different sections of the prostate gland from all of the mice that were fed with water only. Surprisingly, examination of all of the prostate section revealed that none of the mice that were fed with PSP bare any prostate tumors , suggesting that PSP treatment completely inhibited prostate tumor formation in the TgMAP mice. Meanwhile, whereas three of the PSP-fed mice were found to have PIN, the other two mice were found to have completely normal prostates . Furthermore, consistent with the low toxicity of PSP, long term consumption appears to have no side effect on the mice, as judged by the body weight changes and physical signs . These findings strongly suggest that oral intake of PSP may be a safe and effective chemopreventive agent against prostate cancer.
Effect of PSP on prostate tumor development of the TgMAP transgenic mouse model.
What Is The Best Time To Take Turkey Tail Mushroom
It is worth noting that the performance of the turkey tail mushroom is not affected by the time the mushroom is taken. As long as you are taking the right dosage for the functional mushroom, the time you consume turkey tail does not matter.
In most cases, however, the ideal time to take the functional mushrooms is often affected by the reason behind taking the mushroom. To give you an example of other popular functional mushrooms, for people who want to enjoy the reishi mushroom sleep benefits, taking the mushroom before dinner offers more benefits compared to taking the mushroom in the morning. The same case applies to when people take cordyceps pre-workoutthe mushroom offers maximum workout benefits if it is taken a few hours before heading to the gym.
This tells you that for you to figure out the best time to take Turkey tail, you have to consider your end goal.
For example, for people who need a bust of energy during their morning workout, taking the mushroom in the morning is a good idea. However, for people taking it to enjoy the turkey tail mushroom sleep benefits, the best time to take the mushroom is at night, just before going to bed.
If you are asking yourself the question, “does turkey tail mushroom make you high?”, chances are that you are worried the mushroom may affect your mood and performance if you take it in the morning. The good news, however, is that the mushroom does not make you high.
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What Type Of Turkey Tail And Cbd For Cancer
First, for the turkey tail, our preference is for Stamet’s line.
Watch the documentary Fantastic Fungi. This person has lived and breathed mushrooms for decades now.
The fact that he started a company-specific to mushrooms like turkey tail is high on our wishlist.
Again, they have a turkey tail and a general mycommunity brand.
The company recommended both and that’s what we did. You can also look at powders but again, we really trust Stamet’s knowledge base.
As for CBD, there are basic requirements:
Okay…first the THC piece.
THC is also a cannabinoid and it also can have anti-tumor effects. Two things…it doesn’t appear to be “selective” like CBD meaning that it applies the same effect to all cells.
For example with glioblastoma:
Fda Approves Bastyr Turkey Tail Trial For Cancer Patients
It’s been brewed for thousands of years as a Chinese medicinal tea. Now Bastyr University researchers are closer to discovering whether the turkey tail mushroom can help cancer patients boost their immune systems during chemotherapy.
Turkey tail, named for its colorful stripes, is the humble fungus at the center of a $5.4 million collaboration between Bastyr, the University of Washington and others, funded by the National Institutes of Health . The mushroom grows widely in forests around the world, but its health potential has never been fully measured in scientific trials.
The U.S. Food and Drug Administration recently approved a clinical trial for a turkey tail extract, allowing patients with advanced prostate cancer to take it in combination with conventional chemotherapy. Another trial pending FDA approval will test the effects of taking the extract along with a vaccine treatment in women with breast cancer. These will help researchers gather safety data and continue their development of potentially transformative cancer therapy.
“We didn’t discover turkey tail,” says lead investigator Leanna J. Standish, PhD, ND, LAc, FABNO, medical director of the Bastyr Integrative Oncology Research Center. “It’s been used in Asia for thousands and thousands of years, and it turns out to be a really potent immune therapy. The significance, I think, is that we’re bringing a new medicine to cancer patients in the U.S.”
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Cbd And Cancer Cell Death
Where turkey tail was pretty straightforward , CBD comes at it from so many different angles.
Again, our immune system is like a labyrinth with 100’s of not 1000’s of players.
A quick look at cancer cell death is a perfect example. The technical term for cell death is apoptosis.
First breast cancer:
Turkey Tail And Polysaccharide
| 5-y survival:79.0% versus 72.2% | Mitomycin-C plus long-term administration of oral fluorinated pyrimidines | 1iB |
References
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Medicinal Mushrooms Patient Version
On This Page
Medicinal mushrooms are mushrooms that are used as medicine. They have been used to treat infection for hundreds of years, mostly in Asia. Today, medicinal mushrooms are also used to treat lung diseases and cancer. For more than 30 years, medicinal mushrooms have been approved as an addition to standard cancer treatments in Japan and China. In these countries, mushrooms have been used safely for a long time, either alone or combined with radiation or chemotherapy.
In Asia, there are more than 100 types of mushrooms used to treat cancer. Some of the more common ones are Ganoderma lucidum , Trametes versicolor or Coriolus versicolor , Lentinus edodes , and Grifola frondosa .
Mushrooms are being studied to find out how they affect the immune system and if they stop or slow the growth of tumors or kill tumor cells. It is thought that certain chemicalcompounds, such as polysaccharides in turkey tail mushrooms, strengthen the immune system to fight cancer.
This PDQ cancer information summary gives an overview of the use of medicinal mushrooms in treating cancer. The following information is given for Trametes versicolor, also called Coriolus versicolor , and Ganoderma lucidum :
- How it is given or taken.
- Reviews of laboratory and animal studies.
- Results of clinical trials .
A Quick Intro To Cancer
We need to touch base on this as it will help everything that follows make much more sense.
What exactly is cancer?
Simply put, it’s a breakdown in the cellular birth/death cycle.
We have complicated pathways that govern cell birth, death, and replacement.
This is largely managed by our immune system of all things.
Cancer occurs when this system breaks down and cells don’t die.
There are two technical terms you need to understand before looking at turkey tail or CBD.
Okay that sounds technical but let’s simplify.
What happens if a cell starts to malfunction ?
- First, there are sensors that detect that things are not alright
- Next, the immune system is sent into trigger cell death. Cell suicide essentially.
Or the immune system carries out the execution itself and literally “eats” the dysfunction cell.
This is called autophagy. Phage from the Latin word “mouth”.
Cancer occurs when this system breaks down.
A few chinks in the army of many:
- The cancerous cell can hide from the immune system
- The cancerous cell can turn of the suicide instructions
- The cancerous cell can avoid immune attack
So…a breakdown in the orderly demise of cells that are past their prime or broken.
In a nutshell…that’s cancer!
Just remember apoptosis as you’re going to see it over and over again.
Let’s meet the players that carry out the immune system’s orders as they will also pop up.
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