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Are There Side Effects Of A Prostate Biopsy

What to Expect from a Prostate Biopsy

There are complications that may occur as a result of your biopsy. Your consultant will explain all of these before your procedure.

You should let us know straight away if you have any signs of infection after your procedure, including:

  • A high temperature
  • A lot of difficulty passing urine
  • A need to pass urine very often
  • A lot of blood in your urine or stool
  • Shivering or shaking

Other side effects may include:

  • A small amount of blood in your urine and stool
  • A small amount of blood in your semen this wont harm you or your sexual partner
  • Bruising in your back passage or around the insertion site
  • Discomfort in your prostate caused by the bruising
  • Difficulty in getting or maintaining an erection

Prepare For The Immediate Complications

A prostate biopsy usually has the primary complication of bleeding. You can see blood in the urine, in the stool, or in your semen. Also, you may feel pain in your pelvic floor for up to one week. You need to understand before the procedure why this happens. That way, you will be able to tell when the bleeding is too much. Be sure to ask your doctor what to expect in your case.

Why Is A Prostate Biopsy Done

A prostate biopsy is done to screen for prostate cancers. This is to confirm whether cancer is present, or if a prostate cancer diagnosis is aggressive. In a prostate biopsy, small samples of the prostate are removed and then observed under the microscope. Doctors usually recommend a biopsy of the prostate gland based on certain findings.;

  • If prostate-specific antigen blood test results are higher than the average age
  • If the doctor detects signs of a prostate problem during a digital rectal exam
  • If a biopsy is the only method to confirm the cancer

A prostate biopsy involves:

  • Collecting minute samples of the prostate gland. A computed tomography or magnetic resonance imaging scan is also used to guide them through the procedure.
  • A prostate biopsy takes about 10 minutes and is usually done in the doctors office. The samples will be sent to a lab and will be looked at under a microscope to see if they contain cancer cells.
  • If cancer is detected in the patient, it will also be assigned a grade. The results are available after one to three days, but it can sometimes take longer.

A prostate biopsy may be done in several different ways which may include:

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Psa Guidelines For A Biopsy

A prostate biopsy is normally recommended when the PSA blood test values are > 4 ng/mL.If the values are between 2.6 4 ng/mL, then a prostate biopsy is optional.

If the rate of change of PSA values over a period of at least 18 months is found to be > 0.35 ng/mL/year, then a prostate biopsy is recommended.

If a patient with normal DRE and PSA between 4 10 ng/mL cannot be biopsied, then percent-free PSA levels can be used for management.

  • If percent-free PSA levels are >25% then annual follow ups with DRE and percent-free PSA may be considered.
  • If percent-free PSA levels are between 10-25%, a prostate biopsy is preferrable.
  • If percent-free PSA levels are <10%, a prostate biopsy is highly recommended.

Other Factors to Consider

In men with two prior negative extended-pattern prostate biopsies, a saturation biopsy may be done in selected situations like :

  • elevated PSA that is persistently rising,
  • or histologic evidence of atypical cells ,
  • or high grade intraepithelial neoplasia on prior prostate biopsy.

What Happens During An Ultrasound Guided Prostate Biopsy

Prostate Biopsy

During the procedure, you will be asked to lie on your left side, with your legs bent up.

The radiologist will first carry out a DRE with a gloved finger.An ultrasound probe, which is about the thickness of a thumb, will then be inserted into your rectum. The probe is sterilised, covered with two condoms to ensure protection from any infection or contamination, and a lubricant to help it glide easily into your rectum.

Sometimes an injection of local anaesthetic or sedative may be given into the area of your rectum to minimise discomfort during the procedure.

Often the procedure is carried out after you have been given a light general anaesthetic, which means you will be asleep or sedated during the procedure.

After having examined your prostate with the ultrasound, the radiologist will then take biopsies. To take the biopsies, a very fine needle is guided, using pictures or images the radiologist can see on the ultrasound screen, through the wall of your rectum into the prostate and a sample of tissue is taken. The sample is sent to a pathology laboratory for analysis by another specialist doctor called a pathologist.

This biopsy sampling is repeated several times to ensure that any visible abnormal area is adequately sampled, and that as much of the prostate gland as is necessary is also sampled. Usually, between six and 14 individual samples will be taken and sent for analysis.

This approach is used if:

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Alternatives To A Prostatebiopsy

When you need a prostate biopsy to complete the diagnosis and the Gleason score, no other diagnostic tool has the same value. However, there is a gray zone, in which doctors are not sure if the patient has prostate cancer or not. Many patients in this gray zone undergo a prostate biopsy that could be avoided by considering other options.

Depending on your case, one of these alternatives could rule out the suspicion of prostate cancer and disregard the need for a prostate biopsy:

  • Advanced PSA test measures such as PSA density or PSA velocity, especially in patients with known benign prostatic hyperplasia
  • A prostate MRI scan to see a more detailed picture of the prostate
  • Additional prostate markers such as PCA3, T2:ERG, and the MIPS prostate score
  • Watchful waiting, which is recommended for some patients in the gray zone

What Does A Prostate Biopsy Involve

If you decide to have a biopsy, youll either be given an appointment to come back to the hospital at a later date or offered the biopsy straight away.

Before the biopsy you should tell your doctor or nurse if youre taking any medicines, particularly antibiotics or medicines that thin the blood.

You may be given some antibiotics to take before your biopsy, either as tablets or an injection, to help prevent infection. You might also be given some antibiotic tablets to take at home after your biopsy. Its important to take them all so that they work properly.;

A doctor, nurse or radiologist will do the biopsy. There are two main types of biopsy:

  • a trans-rectal ultrasound guided biopsy, where the needle goes through the wall of the back passage
  • a transperineal biopsy, where the needle goes through the skin between the testicles and the back passage .

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What Is A Prostate Biopsy

The prostate gland is found only in males. It sits below the bladder andwraps around the urethra . Theprostate helps make semen.

A biopsy is a procedure used to remove a small piece of tissue or cellsfrom the body so it can be examined under a microscope.

In a prostate biopsy, prostate gland tissue is taken out with a biopsyneedle or during surgery. The tissue is checked to see if there are canceror other abnormal cells in the prostate gland.

A prostate biopsy may be done in several different ways:

  • Transrectal method. This is done through the rectum and is the most common.

  • Perineal method. This is done through the skin between the scrotum and the rectum.

  • Transurethral method. This is done through the urethra using a cystoscope .

Ultrasound is usually used to look at the prostate gland and guide thebiopsy needle.

What Are The Different Types Of A Prostatebiopsy Procedures

Prostate Needle Biopsy

A prostate biopsy is one of the last steps down the road after measuring prostate-specific antigen in the blood, performing a digital rectal examination, and considering each patients risk factors and symptoms.

The main goal is to obtain a prostate sample, especially if there is a visible lesion or tumor. But there are several ways to get this biopsy sample. The most common types are as follows:

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What Are The Advantages And Disadvantages Of Having A Biopsy

Your doctor should talk to you about the advantages and disadvantages of having a biopsy. If you have any concerns, discuss them with your doctor or specialist nurse before you decide whether to have a biopsy.


  • Its the only way to find out for certain if you have cancer inside your prostate.
  • It can help find out how aggressive any cancer might be in other words, how likely it is to spread.
  • It can pick up a faster growing cancer at an early stage, when treatment may prevent the cancer from spreading to other parts of the body.
  • If you have prostate cancer, it can help your doctor or nurse decide which treatment options may be suitable for you.
  • If you have prostate cancer, youll usually need to have had a biopsy if you want to join a clinical trial in the future. This is because the researchers may need to know what your cancer was like when it was first diagnosed.


Is Coffee Bad For Prostate

Drinking four to five cups of coffee every day can lower your chances of fatal and high-grade prostate cancer, according to a 2014 review of clinical studies. Regardless of how many cups you drink overall, every three cups of coffee you drink can reduce your risk of fatal prostate cancer about 11 percent.

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What Does My Prostate Do

The prostate is beneath the bladder and in front of the rectum. Itâs a walnut-shaped gland that surrounds part of the urethra. . Hereâs what it does:

  • It produces fluid for semen, which includes sperm produced in the testicles.
  • It prevents urine from being included during ejaculation.

If it gets too big, your prostate can block pee from passing through the urethra and out the penis.

Lymph Node Biopsy As A Separate Procedure

General information

A lymph node biopsy is rarely done as a separate procedure. Its sometimes used when a radical prostatectomy isnt planned , but when its still important to know if the lymph nodes contain cancer.

Most often, this is done as a needle biopsy. To do this, the doctor uses an image to guide a long, hollow needle through the skin in the lower abdomen and into an enlarged node. The skin is numbed with local anesthesia before the needle is inserted to take a small tissue sample. The sample is then sent to the lab and looked at for cancer cells.

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Other Types Of Prostate Biopsies

While the transrectal prostate biopsy is the most common, there are other types of biopsies that your urologist may perform.

Transperineal biopsy

Done under local or general anesthesia, this biopsy takes prostate samples by inserting a needle through the skin of the perineum .; As this procedure allows a larger area of tissue to be examined than a transrectal biopsy, your urologist may order one if they think you have cancer despite a negative transrectal biopsy.

Transurethral biopsy

Done under local or general anesthesia, this biopsy goes through the urethra to collect the prostate samples. To do this, the urologist inserts a thin tube with a camera attached into the penis. A surgical tube is then passed through the cystoscope to collect the samples.

Use In Men Already Diagnosed With Prostate Cancer

The PSA test can also be useful if you have already been diagnosed with prostate cancer.

  • In men just diagnosed with prostate cancer, the PSA level can be used together with physical exam results and tumor grade to help decide if other tests are needed.
  • The PSA level is used to help determine the stage of your cancer. This can affect your treatment options, since some treatments are not likely to be helpful if the cancer has spread to other parts of the body.
  • PSA tests are often an important part of determining how well treatment is working, as well as in watching for a possible recurrence of the cancer after treatment .

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Why And How Prostate Biopsy Is Done

It is important to know how the prostate biopsy is done, especially if you are a man over 50 who has an elevated risk for prostate cancer.

Your doctor may recommend a prostate biopsy if they suspect that you have cancerous cells in your prostatic tissue.

If left untreated, these cells can lead to problems with bladder control and sexual function.

Prostate biopsies are typically performed outpatient under sedation or general anesthesia with the patient awake throughout the procedure.

How Do You Prepare For A Prostatebiopsy

Transperineal Prostate Biopsy In Local Anesthesia

If you were ordered a prostate biopsy, its because your doctor examined your case and determined that youre a candidate. He has probably told you what it is about, which method hes going to use, and how it will be like. But if you havent discussed everything with your doctor, that is one of the first things on your list. Talk to your doctor and ask him any question you have. Every one of us has different traits and risk factors. You may need specific advice according to your case.

You will probably undergo these preparation steps before a prostate biopsy:

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To 7 Days Before Your Procedure

You may need to stop taking some of your usual medications before your surgery. Examples include anticoagulants, aspirin, medications that contain aspirin, and vitamin E. Follow your healthcare providers instructions.

You can read about medications that contain aspirin and vitamin E in the resource Common Medications Containing Aspirin, Other Nonsteroidal Anti-inflammatory Drugs , or Vitamin E.

What Are The Side Effects Of A Biopsy

Having a biopsy can cause side effects. These will affect each man differently, and you may not get all of the possible side effects.

Pain or discomfort

Some men feel pain or discomfort in their back passage for a few days after a TRUS biopsy. Others feel a dull ache along the underside of their penis or lower abdomen .;If you have a transperineal biopsy, you may get some bruising and discomfort in the area where the needle went in for a few days afterwards.

If you receive anal sex, wait about two weeks, or until any pain or discomfort from your biopsy has settled, before having sex again. Ask your doctor or nurse at the hospital for further advice.

Some men find the biopsy painful, but others have only slight discomfort. Your nurse or doctor may suggest taking mild pain-relieving drugs, such as paracetamol, to help with any pain.

If you have any pain or discomfort that doesnt go away, talk to your nurse or doctor.

Short-term bleeding

Its normal to see a small amount of blood in your urine or bowel movements for about two weeks. You may also notice blood in your semen for a couple of months it might look red or dark brown. This is normal and should get better by itself. If it takes longer to clear up, or gets worse, you should see a doctor straight away.


Symptoms of a urine infection may include:

  • pain or a burning feeling when you urinate
  • dark or cloudy urine with a strong smell
  • needing to urinate more often than usual
  • pain in your lower abdomen .

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What Are The Different Types Of A Prostate Biopsy Procedure

The surgeon can choose any of the three different ways of performing a prostate biopsy. These are as follows:

  • Transrectal method: This is the most common method of performing a prostate biopsy. In this, the surgical instruments are inserted through the rectum .
  • Perineal method: This is done through the area lying between the scrotum and rectum.
  • Transurethral method: A cystoscope is inserted through the urethra .

Talk With Your Healthcare Provider

12 needle biopsy? UPDATE in OP

Tell your healthcare provider if you:

  • Take anticoagulants . These are medications that affect the way your blood clots.
  • Take steroids, such as prednisone .
  • Take any other medications, including vitamin E, multivitamins, herbal remedies, or any other dietary supplements or home remedies.
  • Have taken any antibiotics in the past 3 months.

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Learn The Statistical Likelihood Of Aggressive Prostate Cancer

If a doctor recommends a biopsy based on the results of a PSA test or screening, patients shouldnt automatically jump to unfavorable conclusions. According to a 2018 study in the Saudi Journal of Anesthesia, men who undertake a transrectal ultrasound-guided prostate biopsy often exhibit high levels of psychological stress, which can be attributed to the fear of a cancer diagnosis or to the uncomfortable nature of the screening. For those who are anxious about the findings a screening may uncover, patients can manage their stress level ahead of the procedure by educating themselves about the statistical likelihood of contracting an aggressive prostate cancer.4

According to the American Cancer Society, one man out of nine will be diagnosed with prostate cancer within his lifetime. While prostate cancer is very common in men age 65 or older, most prostate cancer diagnoses are not fatal.7

Dr. Richard Hoffman confirms that The five-year survival for men who have prostate cancer confined to the prostate gland is nearly 100 percent; this drops to 30 percent for men whose cancer has spread to other areas of the body. However, many early-stage cancers are not aggressive, and the five-year survival for those will be nearly 100 percent even without any treatment.6

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