Johnson And Johnson Prostate Cancer

What Are The Harmful Effects Of Johnson’s Baby Powder

Talc inhalation can cause wheezing, coughing, chest pain and difficulty breathing. Although rare, talcum poisoning can prove fatal. Because of these risks, Johnson & Johnson includes a warning on its baby powder product. It says to keep the powder away from your child’s face to avoid inhalation…. see details

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Castration-Resistant Prostate Cancer /HRPCA Therapeutics Marketing introduction

-Explanation

The Report Answers the Following Questions about Castration-Resistant Prostate Cancer /HRPCA Therapeutics

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What Causes Prostate Cancer

The following are also associated with an increased risk of advanced prostate cancer: Height, high body mass index, low physical activity, smoking, low tomato sauce consumption, high calcium intake, high linoleic acid intake, African-American race, and a positive family history…. read more

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• Ora’s Amazing Herbal Baby Powder.
• Ora’s Amazing Herbal Pure and Simple Body Powder.
• Bee All Natural Organic Baby Powder.

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Q: Why Is There Such An Urgent Need For Treatments For This Type Of Prostate Cancer

We know that patients with prostate cancer who have certain mutations face a worse prognosis, but unfortunately there are currently no PARP inhibitor combinations available to them until very late in the disease. We are evaluating the benefits and the risks of giving these combination treatments earlier in metastatic disease progression, before patients receive treatments like chemotherapy.

Current treatment guidelines in the U.S.recommend that all patients with metastatic prostate cancer, and some with localized prostate cancer who have identified risk factors such as a family history of the disease, receive genetic testing. But many patients with prostate cancer arent routinely screened for these relevantmutations, which may also impact treatment.

For example, a survey published earlier this year in the Journal of the Canadian Urological Association found that only a little over a third of oncologists recommended that their patients with newly diagnosed metastatic prostate cancer go for genetic testing. And a recent analysis of more than 5,000 U.S. patients with metastatic prostate cancer found that only 13% had documented genetic testing.

Our Heritage In Prostate Cancer

At Janssen Oncology, we have a legacy of innovation in prostate cancer treatment. We’ve been actively engaged in prostate cancer care for a decade. From our first approval in 2011, we have continued to build on the insights from our clinical research, leading us to five approved indications in prostate cancer.

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A Phase Ii Study Of Jnj

Disclaimer

Clinical study data provided through this site do not replace the official labeling of a given drug product, which presents benefits and risks of the product for approved use. Before prescribing any product, health care professionals should consult the current prescribing information approved in their country. Patients seeking information may consult with their health care professional about the product, for which health authority approved written patient information may be available.

Our Focused Approach To Research

We have already seen the development of trials that incorporate early intermediate endpoints, such as metastasis-free survival. Metastases are a major cause of symptoms, complications and deaths in prostate cancer, so delaying their onset could lead to both an increase in survival and a delay in progression.

We are also combining clinical data and artificial intelligence to help analyse prostate cancer patient data collected in electronic health records in several European, Middle Eastern and African countries. This allows us to more accurately understand and describe the epidemiology, diagnosis and management of prostate cancer, as well as help inform our future approaches to research and treatment combinations.

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What You Need To Know About The Prostate Johnson And Johnaon Prostate Cancer Drugs

A enlarged prostate can also cause blockages in the urethra. A blocked urethra can also damage the kidneys. A patient suffering from an enlargement of the prostate may have pain in his lower abdomen and genitals. If pain is present, a digital rectal examination will reveal hard areas. A doctor may prescribe surgery or perform an endoscopic procedure. If the enlarged prostate is not completely removed, it will shrink.

While the size of an enlarged prostate will influence the extent of urinary symptoms, men may experience a range of urinary symptoms. Some men have minimal or no symptoms at all. Some men will have a very enlarged prostate, whereas others will have a mild enlargement. Generally, the symptoms can stabilize over time. Some men may have an enlarged prostate but not notice it. If they have an enlarged colon, their physician can perform a TURP procedure.

Some Men With Prostate Cancer May Not Need Immediate Treatment

If youre diagnosed with early, low-risk prostate cancer, experts now believe you may not need to do anything about it at first.

Sometimes tumors are so small, and grow so slowly, that its reasonable to just monitor them closely, which is a process known as active surveillance, Dr. Smith says.

A landmark study that followed 1,643 men with low-risk prostate cancer found that whether they opted for surgery, radiation therapy or active surveillance, their survival rates were about the same: Each group had a prostate cancer-related death rate of about 1%.

Note, though, that if you do opt for active surveillance, youll still need to be monitored with periodic biopsies, prostate exams and PSA blood tests every six to 12 months, Dr. Smith says. If the cancer should show signs of progression, youll need to start active treatment.

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Can Talcum Powder Give You Prostate Cancer

The possible cancer risk associated with talcum powder is uncertain, since studies have produced a range of findings. There is a stronger suggestion that talcum powder may be linked to ovarian cancer risk, but there is no similar evidence directly connecting talc and testicular cancer…. view details

J& j Gets Ema Nod For Wider Use Of Erleada In Prostate Cancer

Maintains a regulatory lead over rival Xtandi

Johnson & Johnson has clinched another approval for its prostate cancer drug Erleada in Europe, maintaining a regulatory lead over rival Xtandi from Astellas and Pfizer.

The EMA clearance for Erleada in metastatic castration-sensitive prostate cancer adds another 100,000 European patients to the drugs eligible patient population, says J& Js Janssen pharma unit.

mCSPC accounts for the sizeable proportion of prostate cancer patients who have advanced disease, but whose tumours still remain sensitive to treatment with androgen deprivation therapy based on older, hormonal drugs. In many cases, ADT alone isnt sufficient to keep the disease under control.

Erleada can now be used for mCSPC patients in combination with ADT in Europe ahead of Xtandi , which was approved for this indication in December in the US but still hasnt got the green light in Europe after its filing there last July. Erleada got the go-ahead for mCSPC in the US last September.

Androgen inhibitor Erleada is J& Js follow-up up to big-selling prostate cancer drug Zytiga , which has been hit by the loss of patent protection and generic competition.

Xtandi is now the dominant player in the market by value, with annual sales expected to top $4bn in 2019 while J& J reported another 20% drop in Zytiga to $2.8bn earlier this month.

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Board Certification And Academic Information

Skyler Johnson, MD is an Assistant Professor in the Department of Radiation Oncology at the University of Utah Hunstman Cancer Institute. As a physician and researcher, he has sought to improve the lives of both individuals and the community through exemplary care and expertise in the area of health services research. His clinical specialties include prostate cancer and other genitourinary malignancies as well as gastrointestinal malignancies, lung cancer, and lymphoma. His research interests include comparative effectiveness, patient communication, patient education, clinical outcomes, quality of life research, cost-effectiveness, decision analyses, and clinical trial design.

Dr. Johnson’s research interests and passion for cancer care began during medical school at Michigan State University. He then completed a year-long research fellowship at the University of Michigan in the Department of Radiation Oncology. He completed his residency in radiation oncology at Yale, where he served as Chief Resident. While at Yale, he received additional training as a Health Sciences Research Fellow as part of the Yale National Clinical Scholars Program and a member of the Cancer Outcomes, Public Policy and Effectiveness Research Center group.

Johnson & Johnson’s Prostate Cancer Drug Erleada Wins Nice Approval

• Following a deeper discount, Johnson & Johnson has secured reimbursement in England for its prostate cancer drug Erleada .

• Less than four months ago, the National Institute of Health and Care Excellence rejected Erleada, even though it was offered in England below its list price of £2,735 for a supply of 112 tablets.

• “We are very pleased that Janssen has been able to work with us to address the uncertainties in the evidence identified by the committee in the previous draft guidance,” NICE’s deputy chief executive Meindert Boysen said in a statement.

• Erleada, a once-daily oral androgen receptor inhibitor, works by blocking the effect of testosterone on prostate cancer cells.

• NICE estimates that 8,000 patients deemed unsuitable for standard chemotherapy will be eligible for treatment with the drug.

• Price Action: JNJ shares are down 0.27% at $171.85 during the market session on the last check Wednesday.

See more from Benzinga

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Johnson & Johnson Vs Medivation In Prostate Cancer Race

Xtandi, a prostate cancer drug made by Medivation and Astellas, helped patients to live longer and a Phase 3 trial testing it was cut short for good performance in October.

Xtandi is already approved for patients previously treated with the chemo docetaxel for their mCRPC . Based on the recent results, the makers plan to apply for an extended indication to use it in pre-chemo treatment. Competitor Johnson & Johnson’s Zytiga, in combination with prednisone, has already been approved for that last December.

The approval could be a significant boost to Xtandi: potentially it could turn it into a blockbuster.

Xtandi’s U.S. sales for the third quarter were $108.5 million compared to $82.4 million in the second quarter. Sales outside the U.S. were only $13.0 million, as it was just recently approved in Europe. For the full year 2013, Medivation expects U.S. sales to reach $345 million. Medivation shares equally in the profits and the expenses with Astellas.

Zytiga is already a blockbuster, it sold $1.2 billion worth of drugs in the first 9 months of the year, up 72.6 percent from the same period last year. In the third quarter it has generated $464 million in sales.

With similar efficacy and tolerability profiles, Zytiga and Xtandi are currently competing for first-line status in both the post and pre-chemo settings. Both drugs are set to generate blockbusting revenues in spite of or because of the high prices they charge for the treatment.

Xtandi

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Surgical procedures to remove the diseased prostate are usually necessary. Surgical procedures are not always necessary. If the disease is caused by bacterial infections, a doctor can treat the symptoms using alpha-blockers or surgery. Physical therapy, relaxation exercises, and warm baths are all recommended. A physician may also prescribe antibiotics to cure the infection. A bacterial infection can also cause a recurrence of the condition.

An enlarged prostate can be uncomfortable for both men and women. Some of the symptoms of an enlarged male reproductive organ include a weakened urine stream, urgent need to urinate, and urinary tract infections. BPH can also cause damage to the kidneys. A sudden inability to urinate can be life-threatening, as it can lead to bladder and kidney damage. Unfortunately, most men with enlarged prostrates put up with the symptoms for years before they seek treatment. However, many of the men with symptoms finally decide to go to a doctor for proper gynecological evaluation and to begin enlarged prostatic therapy.

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The Initial Causes Johnson And Johnaon Prostate Cancer Drugs

One of the first symptoms of prostate issues is pain or tenderness in the groin or lower back. This can be the result of a noncancerous condition called enlarged prostatic tissue, or it could be an infection of the bladder. In either case, its important to see a doctor as soon as possible. If youre suffering from prostate pain, you may want to consider reducing your caffeine intake.

Another symptom of a potentially enlarged prostate is difficulty starting a stream of urine, leaking, or dribbling. These symptoms are not serious, but theyre still alarming. Most men put up with an enlarged prostate for years before seeking medical attention, but they typically seek treatment as soon as they notice symptoms. Even if you dont have symptoms, its worth getting checked to determine if you have any prostate issues.

If you experience nightly bathroom runs, you may be experiencing an enlarged prostate. You may be having difficulty starting a stream of urine, or you may even be dribbling or leaking during the day. These problems arent life-threatening, but can become a nuisance. You should not ignore these signs and seek treatment as soon as you notice them. If you feel any of these symptoms, you should consult a doctor.

Common Side Effects People Have Besides Prostate Cancer *:

* Approximation only. Some reports may have incomplete information.

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Symptomatic treatment of an enlarged prostate usually involves a combination of medication and lifestyle changes. A diet rich in fruits and vegetables may be the best option if you suffer from chronic urination. It will help the body adjust to the increased size of the prostate. Also, taking regular urination intervals will help retrain the bladder to function properly. Inactivity also contributes to urine retention, and cold temperatures can increase the urge to urinate.

Invasive treatment of enlarged prostate includes medication that relieves the pressure on the urethra and bladder. However, if the condition is severe, it may require surgical intervention. If treatment is not successful, the enlarged prostate can become a potentially life-threatening disease. As the hormone levels in the body change, the enlarged prostate can lead to various complications, including urinary retention and even cancer. This is why it is critical to see a doctor for further evaluation.

Q: What Do You Love Most About Your Work

The mission and the dogged approach to cure and prevent this horrible disease. I made the switch from the academic setting to oncology in 2006, when I began working for a different pharmaceutical company because I wanted to help more patients on a global scale. I moved to Johnson & Johnson in 2013 to work on a multiple myeloma medication. My sister had just been diagnosed with multiple myeloma, and Janssen was making fantastic progress in the field. I wanted to help her, and thousands of patients like her.

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Fda Approves J& j’s Prostate Cancer Drug Erleada In New Use As Zytiga Sales Fall

The FDA has approved Johnson & Johnsons prostate cancer drug Erleada for patients whose prostate cancer has spread.

Already on the market for patients in the early stages of the disease, this new indication in metastatic castration-sensitive prostate cancer follows a fast review from the FDA.

Approval from the FDA means that J& Js Janssen unit has stolen a march on its rivals who are also developing drugs for this niche Pfizer/Astellas with Xtandi , Bayer/Orions Nubeqa , and Takedas orteronel.

Erleada is a successor to J& Js Zytiga , which has gone off patent in the US and succumbing to generic competition sales of the blockbuster were down nearly 60% in Q2 in the US to $198 million, with worldwide sales down 23% to $698 million.

But after a first approval in February last year in non-metastatic castration-resistant prostate cancer, Erleada has yet to make a significant impact on sales and J& J will hope that the new indication will allow it to gain traction.

Sales of Erleada are expected to be just over $1.5 billion by 2022, with increased competition from Xtandi in metastatic castration-resistant disease taking the edge off the drugs performance on the market.

Data from the TITAN trial that supported the filing was published at ASCO, and the new use will make the androgen receptor inhibitor available for the approximately 40,000 people in the US diagnosed with mCSPC annually.

We Collaborate To Innovate

Our ultimate goal is to change what it means to have, and to treat, cancer. We know that change can only come through collaboration and we invest our time, expertise and resources and partner with experts to unlock the potential around us, all in pursuit of better outcomes for patients and their families.

Working with cross-industry partners, such as Astex Therapeutics, we are bringing to life our commitment to precision medicines. These partnerships include leveraging computational tools and AI to provide real world data-driven understanding to enable superior clinical decision-making and ultimately improve outcomes.

Patterns, correlations and new hypothesis identified through AI will be incorporated into clinical trials, making them more efficient, accurate and safe. The use of Big Data is particularly relevant for prostate cancer due to the multiple, interacting biological, epidemiological, clinical, environmental, psychosocial and lifestyle-related variables that exist in a long-term disease course.

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