Prostate Urine Risk Tests
As fluid moves from the prostate through the urethra, it carries cancer cells and RNA with it. Once the body has passed this genetic and cellular information out in the urine, scientists can use it to detect clues about the presence of prostate cancer.
These tests are called prostate urine risk tests, and predict whether or not prostate cancer will become aggressive.
In earlier studies of PUR tests, before researchers collected a urine sample, they conducted a digital rectal exam. As the authors of the new study explain, during the exam, a doctor will firmly stroke one side of the prostate. This encourages cellular and genetic material to move from the prostate to the urine sample.
Digital rectal exams are unpopular and require a trip to the doctors office. Researchers from the University of East Anglia in the United Kingdom wanted to determine whether or not it would be possible to skip this procedure while still yielding accurate PUR results.
Their recent study investigated an at-home version of the PUR test. At-home testing allows participants to take a urine sample at home and mail it to the laboratory. This is ideal, because it means that the person can capture the first urination of the day.
As lead researcher Dr. Jeremy Clark explains, Because the prostate is constantly secreting, the collection of urine from mens first urination of the day means that the biomarker levels from the prostate are much higher and more consistent.
Do False Negatives And False Positives Happen
The PSA test is not a fool-proof method to test for prostate cancer.
When prostate cancer develops, PSA levels often rise about 4.0 ng/mL, but there are exceptions to the rule.
A showed that some people with PSA levels below 4.0 ng/mL had prostate cancer, while some with higher levels did not.
The ACS states that about of people with a PSA below 4 will have prostate cancer.
Scientists Develop Home Urine Test Kit That Can Accurately Spot Prostate Cancer Risk
The research team hopes that the introduction of the At-Home Collection Kit could revolutionise diagnosis of the disease.
Scientists have developed a novel urine test kit that can help detect prostate cancer risk at home. The test diagnoses aggressive prostate cancer and predicts whether patients will require treatment up to five years earlier than standard clinical methods.
The PUR test could be performed on samples collected at home, so men dont have to come into the clinic to provide a urine sample or have to undergo an uncomfortable rectal examination, according to researchers from the University of East Anglia and the Norfolk and Norwich University Hospital.
This is an important step forward, because the first urination of the day provides biomarker levels from the prostate that are much higher and more consistent.
The research team hopes that the introduction of the At-Home Collection Kit could revolutionise diagnosis of the disease.
Prostate cancer usually develops slowly and the majority of cancers will not require treatment in a mans lifetime. However, doctors struggle to predict which tumours will become aggressive, making it hard to decide on treatment for many men, said lead researcher Dr Jeremy Clark from UEAs Norwich Medical School.
The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination , an MRI scan or a biopsy.
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Improving Upon The Psa Test
The limited reliability of the PSA test, and its lack of specificity for prostate cancer, has led to sharp disagreement over the use of the PSA test as a routine health screening measure for men of a certain age. What everyone does agree upon is the need for better markers of prostate cancer. To date there are no perfect biomarkers that identify only high-risk prostate cancer. But each year progress is made toward such a goal. Today, the University of Michigans Department of Pathology MLabs will begin offering the MiPS urine test that is ultra specific for prostate cancer. The MiPS test scans urine samples for two molecular markers that are distinct to prostate cancer. One marker is a snippet of RNA made from a gene that is overactive in 95 percent of all prostate cancers. The second marker is RNA that is made only when two genes abnormally fuse. The presence of this fusion RNA in a mans urine is ultra specific for prostate cancer.
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When Should I Get A Prostate Urine Test
The American Cancer Society recommends that all men over the age of 50 get a prostate urine test. If youre concerned about prostate cancer, talk to your doctor about getting a test earlier.
A prostate urine test is an important tool for detecting prostate cancer. The test can help identify men who may have prostate cancer, and it can help determine the severity of the disease.
If youre concerned about prostate cancer, talk to your doctor about getting a prostate urine test. This simple and easy test can help you determine your risk for this serious disease.
There you have it: everything you need to know about the prostate urine test. So, if youre over 50 and have been wondering whether or not you should get tested, now you know that the prostate urine test is a simple and easy way to find out.
And dont forget: the test is affordable and available at most drugstores. So go ahead and get tested today!
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Urine Test Can Help Diagnose Aggressive Prostate Cancer
Recent research has revealed that a new urine test can detect aggressive prostate cancer cases that need treatment up to 5 years sooner than other diagnostic methods.
Researchers from the University of East Anglia in Norwich, United Kingdom, and the Norfolk and Norwich University Hospital carried out the study.
They revealed that an experimental urine test, called Prostate Urine Risk , can distinguish who will and who will not require treatment within the first 5 years of diagnosis.
The findings now appear in the journal BJU International.
Prostate Cancer News
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What Is The Prostate Urine Test
The prostate urine test is a simple and non-invasive way to check for prostate cancer. This method is called the PUR test .
The PUR test , is designed to be used first thing in the morning and shows biomarkers associated with prostate cancer far more clearly than after a digital rectal exam.
The PUR test is a simple, fast, and non-invasive way to check for prostate cancer. Home collection kits are available so you can do the test in the privacy of your own home.
The test looks for two biomarkers in urine that are associated with prostate cancer: 3-methylhistidine and prostate-specific antigen .
3-methylhistidine is a protein that is produced at high levels when the tumor is growing. PSA is a protein that is produced by the prostate gland and can be elevated in men with prostate cancer.
According to some researchers, the PUR test is able to spot men who are up to eight times less likely to need radical treatment within five years of diagnosis.
It offers clues about who might need treatment five years sooner than current tests.
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When To See A Doctor
If you have elevated PSA levels, its best to schedule an appointment with a doctor. High PSA levels alone arent enough to diagnose any one condition because they can be elevated in several prostate conditions. Meeting with a doctor for further testing can help find the cause of the elevated levels and receive early treatment.
Prostate Cancer Home Test Kits
If youre worried about your risk of prostate cancer, then look out for early signs with a prostate cancer home test kit from our collection at Home Health UK. With a prostate cancer test kit designed for at-home use, you can carry out your test in the comfort and privacy of your own home and wait for the results on your own terms.
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Urine Test Could Help Prevent Cervical Cancer: Study
Prostate cancer usually develops slowly and the majority of cancers will not require treatment in a mans lifetime. However, doctors struggle to predict which tumours will become aggressive, making it hard to decide on treatment for many men, said lead researcher Dr Jeremy Clark from UEAs Norwich Medical School.
The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination , an MRI scan or a biopsy.
We developed the PUR test, which looks at gene expression in urine samples and provides vital information about whether a cancer is aggressive or low risk.
The research team provided 14 participants with an At Home Collection Kit, and instructions.
They then compared the results of their home urine samples, taken first thing in the morning, with samples collected after a digital rectal examination.
We found that the urine samples taken at home showed the biomarkers for prostate cancer much more clearly than after a rectal examination. And feedback from the participants showed that the at home test was preferable, the authors wrote in a paper published in the journal BioTechniques.
Because the prostate is constantly secreting, the collection of urine from mens first urination of the day means that the biomarker levels from the prostate are much higher and more consistent, so this is a great improvement, they added.
University Of East Anglia Researchers Develop Non
Jun 9, 2021 | Instruments & Equipment, International Laboratory News, Laboratory News, Laboratory Pathology, Molecular Diagnostics, Genetic Testing, Whole Gene Sequencing
The researchers believe their test could reduce the number of unnecessary prostate cancer biopsies by 32%, UEA reported
New diagnostic technologies may make it possible for men to provide a urine sample that can allow a clinical laboratory to not only accurately diagnose prostate cancer but also help determine whether it is an aggressive form of prostate cancer. Researchers in the United Kingdom recently described just such a test in an online, peer-reviewed journal.
Development of a non-invasive method of diagnosing prostate cancer would be significant for anatomic pathologists in the United States. In the US alone, approximately 248,000 men will be diagnosed with this type of cancer in 2021. Prostate biopsies represent a major proportion of case referrals to community pathology groups.
Moreover, were such a non-invasive test for prostate cancer also able to identify those individuals with fast-growing prostate cancers, that would help urologists make more informed treatment decisions.
A Disease Men More Commonly Die With Rather than From
The UEA test may also allow for self-collection of the biological sample, and if it proves accurate, the test could bring additional revenue to clinical laboratories that would perform the urine testing.
Possibility of Reducing Needle Biopsies by 32%
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How Long Does It Take To Lower Psa Levels
The amount of time it takes to lower PSA levels depends on whats causing the elevated levels. Mild changes in PSA could return to normal within a few days.
However, if the elevation in PSA is due to prostate cancer, PSA levels will not decrease. For prostate cancer treated with surgery, PSA is expected to be undetectable after 1 month. For prostate cancer treated with radiation, PSA will reach its lowest level after 17 months on the average.
If due to benign prostatic hyperplasia, PSA may not decrease, as prostate size naturally increases with age.
For other conditions, like prostate cancer, it could take 1-2 years after treatment for levels to lower.
Home Urine Test For Prostate Cancer Could Revolutionise Diagnosis
A simple urine test under development for prostate cancer detection can now use urine samples collected at home – according to new research from University of East Anglia and the Norfolk and Norwich University Hospital.
Scientists pioneered the test which diagnoses aggressive prostate cancer and predicts whether patients will require treatment up to five years earlier than standard clinical methods.
The research is published in the journal BioTechniques.
Their latest study shows how the ‘PUR’ test could be performed on samples collected at home, so men don’t have to come into the clinic to provide a urine sample – or have to undergo an uncomfortable rectal examination.
This is an important step forward, because the first urination of the day provides biomarker levels from the prostate that are much higher and more consistent.
The research team hope that the introduction of the ‘At-Home Collection Kit’ could revolutionise diagnosis of the disease.
Lead researcher Dr Jeremy Clark, from UEA’s Norwich Medical School, said: “Prostate cancer is the most common cancer in men in the UK.
It usually develops slowly and the majority of cancers will not require treatment in a man’s lifetime.
However, doctors struggle to predict which tumours will become aggressive, making it hard to decide on treatment for many men.
“The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination , an MRI scan or a biopsy.
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What Is A Dangerous Psa Level
The higher your PSA level, the higher the risk for prostate cancer. While PSA levels may fluctuate during your lifetime, a consistent rise in PSA over time can indicate prostate cancer.
If you have a PSA level , youre considered to be in the borderline range, according to the ACS. You have a 1 in 4 chance of having prostate cancer.
If PSA levels rise above 10, theres a 50 percent chance you have prostate cancer.
Home Urine Test Could Revolutionise Prostate Cancer Diagnosis
Dr Jeremy Clark, from University of East Anglia’s Norwich Medical School, has said the move could “revolutionise diagnosis”.
Friday 29 November 2019 09:21, UK
Scientists have developed a new prostate cancer test which could involve collecting a urine sample at home.
Experts hope to revolutionise diagnosis of the potentially fatal disease by creating an at-home collection kit.
Those who use the kit would then post the sample off for analysis.
The Prostate Urine Risk test is for men suspected of having prostate cancer, and is much more sensitive than current methods.
It picks up how aggressive the disease is, at what point men will need treatment, and rules out those who do not have prostate cancer.
The test cuts down the need for other procedures, including biopsies, blood tests, a physical examination known as a digital rectal examination, or an MRI scan.
It is also suitable for men already diagnosed with low-risk disease who are on a “watch and wait” approach known as active surveillance.
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New Prostate Cancer Urine Test Shows How Aggressive Disease Is And Could Reduce Invasive Biopsies
Published by Communications
Researchers from the University of East Anglia have developed a new urine test for prostate cancer which also shows how aggressive the disease is.
A new study published today shows how an experimental new test called ExoGrail has the potential to revolutionise how patients with suspected prostate cancer are risk-assessed prior to an invasive biopsy.
The research team say their new test could reduce the number of unnecessary prostate cancer biopsies by 35 per cent.
Prostate cancer is the most common cancer in men in the UK. It usually develops slowly and the majority of cancers will not require treatment in a mans lifetime.
The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination , an MRI scan or an invasive biopsy.
However, doctors struggle to predict which tumours will become aggressive, making it hard to decide on treatment for many men.
Lead researcher Dr Dan Brewer, from UEAs Norwich Medical School and also a visiting worker at the Earlham Institute, said: While prostate cancer is responsible for a large proportion of all male cancer deaths, it is more commonly a disease men die with rather than from.
Invasive biopsies come at considerable economic, psychological and societal cost to patients and healthcare systems alike.
The ExoGrail test also provided risk scores for patients and highlighted those for which an invasive biopsy would have been beneficial.
Home Urine Test For Prostate Cancer Reveals Its Most Aggressive Forms
Early diagnosis is pivotal to the treatment of all cancers, but some reveal their machinations far earlier than others. Prostate cancer is unfortunately one that might not show itself until in its later, more aggressive stages, so the search is on for tools that can pick it up earlier in the piece. A new possibility has emerged from the UKs University of East Anglia , where scientists have developed a urine test for the home that can reveal prostate cancers in need of treatment.
A big problem with prostate cancer diagnosis is actually the high rate of unnecessary biopsies, which are costly in terms of resources, but also cause the patient unneeded angst. This is the direct result of the complexities in distinguishing the behavior of a cancerous prostate with a regular one, with both able to present the same biomarkers in the blood.
These are known as prostate-specific antigens , which the prostate produces normally in small amounts. When PSA levels are heightened, doctors will often take a tissue sample for further analysis, as it may be indicative of cancer.
But these spikes can also be the result of other conditions, such as a prostate infection or more innocent tumors that will never require treatment. Up to 75 percent of men with raised PSA levels return negative cancer results following biopsy, according to the UEA team.
The scientists are hopeful the technique could even lead to similar home tests for bladder and kidney cancer.
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